TY  - JOUR
AU  - Arshad, Mohammed Faiz 
AU  - Al-Otaibi, Faisal 
AU  - Mustafa, Gulam 
AU  - Shousha, Saad 
AU  - Alshahrani, Abdulrahman 
PY  - 2019
TI  - β-Naphthalene Incorporated Thiazole-5-Carboxamides/Thiazole -5- Ketones: Design, Synthesis and Anticonvulsant Screening against Two Seizure Models
JF  - American Journal of Pharmacology and Toxicology
VL  - 14
IS  - 1
DO  - 10.3844/ajptsp.2019.27.37
UR  - https://thescipub.com/abstract/ajptsp.2019.27.37
AB  - A bunch of β-naphthalene incorporated thiazole-5-carboxamides/thiazole -5- ketones (7a-7o& 8a-8e) were prepared by reacting 4-methyl-2-(naphthalen-2-yl)thiazole-5-carbonyl chloride with appropriate amines. Structures of all the compounds were explained by elemental analysis, FT-IR, 1H NMR and mass spectral data. The compounds were evaluated for their anticonvulsant activity employing MES and chemoshock (scPTZ) seizure tests. Neurotoxicity was also assessed. Majority of these compounds exhibited significant activity against both animal models; however, compounds 7e, 7j, 7n and 8c displayed promising activity and could be considered as leads for further investigations.