@article {10.3844/ajptsp.2023.9.16,
article_type = {journal},
title = {Optic Neuropathy: Characteristic Pathology for Identifying Drugs with Potential to Cause Mitochondrial Toxicity},
author = {Dyer, Connor and Droke, Katlyn and Zekonyte, Ugne and Rosca, Mariana},
volume = {18},
year = {2024},
month = {Jan},
pages = {9-16},
doi = {10.3844/ajptsp.2023.9.16},
url = {https://thescipub.com/abstract/ajptsp.2023.9.16},
abstract = {Deleterious effects on mitochondria are known to be frequently caused by prescription drugs, however, there is no standard and specific testing by pharmaceutical companies on these effects on mitochondria during drug development. The objective of this study is to determine if cases of optic neuropathy are related to drug-induced mitochondrial toxicity in a way that could be used to predict patient harm. To determine this, all cases of optic neuropathy within a fifty-eight-month timeframe were reviewed in the food and drug administration adverse effect reporting system. The drugs listed as the suspected causes of optic neuropathy in each case were analyzed for frequency of occurrence and frequently occurring drugs were evaluated for documented mechanisms of mitochondrial toxicity. The odds of occurrence of drugs with and without mitochondrial toxicity implemented in these cases were compared with all other adverse drug events excluding optic neuropathy. Our findings indicate that mitochondrial toxicity plays a major role in drug-induced optic neuropathy. We found that the drugs with known mitochondrial toxicity had a 1.47 (95% CI 1.30-1.67, p},
journal = {American Journal of Pharmacology and Toxicology},
publisher = {Science Publications}
}