@article {10.3844/amjnsp.2023.1.11,
article_type = {journal},
title = {Thiosemicarbazide Induces Partial Myoclonic, Generalized Tonic-Clonic and Status Epilepticus Seizures Depending on the Dose in the Rat},
author = {Satef, Anwar and Amoury, Sofia El and Ganouni, Soumaya El and Essamadi, Abdelkhalid and Bagri, Abdallah},
volume = {13},
year = {2023},
month = {Mar},
pages = {1-11},
doi = {10.3844/amjnsp.2023.1.11},
url = {https://thescipub.com/abstract/amjnsp.2023.1.11},
abstract = {The present study aimed to characterize the seizures produced by injections of Thiosemicarbazide (TSC), a glutamic acid decarboxylase inhibitor. It aimed also to evaluate the anticonvulsant effect of the antiseizure medications Phenobarbital (PHB), Valproate (VPA), and Phenytoin (PNT) and of the antipsychotics Chlorpromazine (CPZ) and Haloperidol (HAL) as well as the antidepressant SSRI, Fluoxetine (FXT). Male Wistar rats received TSC i.p. injections of 2.5, 5, 7.5, 10, and 20 mg/kg. The rat's changes in behavior and the onset latencies of seizures were recorded and compared using an ANOVA test whereas the incidences of seizures were compared using a c2 test. Seizure severity was categorized as Partial Myoclonic Seizures (PMS), Generalized Tonic-Clonic Seizures (GTCS), and Status Epilepticus (SE). At low doses, TSC induced a significant change in behavior indicating an anxiety-inducing effect. The threshold dose for PMS was 7.5 mg/kg and when the dose increased to 10 mg/kg, PMS progressed to GTCS. TSC 7.5 mg/kg dose also induced susceptibility to audiogenic seizure (p},
journal = {Neuroscience International},
publisher = {Science Publications}
}