@article {10.3844/ojbsci.2010.151.156,
article_type = {journal},
title = {Bioactive Compounds Screening from Zingiberaceae Family as Influenza A/Swine Flu Virus Neuraminidase Inhibitor through Docking Approach},
author = {Tambunan, Usman Sumo Friend and Fadilah, and Parikesit, Arli Aditya},
volume = {10},
number = {4},
year = {2010},
month = {Dec},
pages = {151-156},
doi = {10.3844/ojbsci.2010.151.156},
url = {https://thescipub.com/abstract/ojbsci.2010.151.156},
abstract = {Problem statement: Influenza A/H1N1 is a disease caused by infection of influenza a virus
subtype H1N1. It is a major health problem in tropical and subtropical countries. This virus constantly
mutates and consequently will be developed into new drug-resistant strains. Approach: In this
research, we have conducted docking study to screen bioactive compounds from Zingiberaceae family,
which has a role as neuraminidase inhibitor of influenza a virus. Results: The docking result identified
that 1, 2-di-O- β-D-glucopyranosyl-4-allylbenzene (BGA) compound has the affinity and ability to
inhibit neuraminidase. There are fourteen residues contact of BGA compound to neuraminidase and
eight residues contact of enzyme that formed hydrogen bond with catalytic site.
Conclusion/recommendation: The docking result showed that BGA has better binding energy and
affinity compared with other bioactive compounds and the standard compounds.},
journal = {OnLine Journal of Biological Sciences},
publisher = {Science Publications}
}