Preparation and Properties of Copolyanhydrides Based on 2-Hexadecylsuccinic Acid and Sebacic Acid
Poly(2-hexadecylsuccinic acid-sebacic acid) (P(HSA-SA)) copolymers have been prepared by melt polycondensation. The copolymers were characterized by FT-IR, 1HNMR, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). In vitro studies showed that all our prepared copolymers are degradable in phosphate buffer at 37°C. The release profiles of hydrophilic model drug, ciprofloxcin hydrochloride, from the copolymers, follow first order release kinetics. All the preliminary results suggested that the copolymer might be potentially used as drug delivery devices.
Copyright: © 2007 Yousef Hamdan, Xiangmei Jiang, Kaixun Huang and Kaichao Yu. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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- melt polycondensation
- in vitro degradation
- drug released