Research Article Open Access

Decreased Intensity of Japanese Encephalitis Virus Infection in Chick Chorioallantoic Membrane Under Influence of Ultradiluted Belladonna Extract

Bhaswati Bandyopadhyay1, Satadal Das2, Milan Sengupta1, Chandan Saha1, Kartick Chandra Das3, Debabrata Sarkar3 and Chaturbhuj Nayak4
  • 1 School of Tropical Medicine, India
  • 2 West Bengal University of Health Sciences, India
  • 3 Drug Proving Research Centre, India
  • 4 61-65 Intitutional Area, India

Abstract

Problem statement: No specific antiviral therapy is currently available despite an emergence and resurgence of Japanese encephalitis in South-East Asian Countries. There are only few recent studies, which were aimed to treat Japanese encephalitis with newer drugs. There is thus a real need for study on antiviral agents that can reduce the toll of death and neurological sequelae resulting from infection with this virus. Approach: Optimum dilution of the JE virus was determined which could produce significant number of pocks on Chorioallantoic Membrane (CAM). Then ultradiluted belladonna preparations were used to see their inhibitory action on JE virus infection in CAM. Results: Ultradiluted belladonna showed significantly decreased pock count in CAM in comparison to JE virus control. Conclusion: Ultradiluted belladonna could inhibit JE virus infection in CAM, which may be mediated through glycosidase inhibitory role of calystegines present in belladonna.

American Journal of Infectious Diseases
Volume 6 No. 2, 2010, 24-28

DOI: https://doi.org/10.3844/ajidsp.2010.24.28

Submitted On: 20 June 2010 Published On: 30 June 2010

How to Cite: Bandyopadhyay, B., Das, S., Sengupta, M., Saha, C., Das, K. C., Sarkar, D. & Nayak, C. (2010). Decreased Intensity of Japanese Encephalitis Virus Infection in Chick Chorioallantoic Membrane Under Influence of Ultradiluted Belladonna Extract. American Journal of Infectious Diseases, 6(2), 24-28. https://doi.org/10.3844/ajidsp.2010.24.28

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Keywords

  • Japanese Encephalitis (JE)
  • Chorioallantoic Membrane (CAM)
  • pock
  • belladonna