Research Article Open Access

Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

T. S. Muralidhar1, Anna Balaji1, Chinmay Bandopadhyay1 and S. L. Shantha2
  • 1 Dayananda Sagar College of Biological Sciences, India
  • 2 People Education Society College, India

Abstract

Problem statement: UlGen, a Polyherbal formulation, was investigated for its possible Ulcero-protective activity in ulcerogen and Cold-restraint stress induced Wister rats (Rattus rattus). Oral administration of UlGen, at a dose of 800 mg kg-1 significantly protected the onset of cold-resistance stress induced ulcerations. Approach: It significantly inhibited gastric ulceration induced by alcohol and aspirin. Control group: Alcohol 80% induced ulcer was 42.00±2.30 and in UlGen treated rats showed 10.00±1.62. Using alcian blue stain to study the mucus secretion by mucosal cells carried out histological examination of gastric glandular mucosa. Results: The volume and acidity of gastric juice in pyloric-ligated rats was reduced in treated rats. Gastric volume (mL 100 g-1) in control rats showed 4.12±0.32 and in UlGen treated rats showed 2.50±0.20. Conclusion: UlGen, Cytoprotective effect may be due to the enhancement of defensive mechanism through an improvement of gastric cytoprotection as well as acid inhibition.

American Journal of Pharmacology and Toxicology
Volume 4 No. 3, 2009, 80-84

DOI: https://doi.org/10.3844/ajptsp.2009.80.84

Submitted On: 22 July 2008 Published On: 30 September 2009

How to Cite: Muralidhar, T. S., Balaji, A., Bandopadhyay, C. & Shantha, S. L. (2009). Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats . American Journal of Pharmacology and Toxicology, 4(3), 80-84. https://doi.org/10.3844/ajptsp.2009.80.84

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Keywords

  • UlGen
  • gastric ulceration
  • cold-resistance stress
  • pyloric-legated
  • gastric cytoprotection
  • ulcer index