Research Article Open Access

Serum TGF-β and TNF-α During Psoriasis Therapy with Narrowband Ultraviolet B

Ahmad Taha Khalaf1 and Yan Yuehua2
  • 1 Department of Dermatology, Faculty of Medicine, Mosul Medical College, Mosul University, Mosul, Iraq
  • 2 Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Abstract

Although it is now an accepted concept that narrow-band UVB therapy is an efficacious therapy for psoriasis, the relationship between the response rate and the potential effects on serum cytokines is less well-established. The purpose of this study was to investigate the correlation between the response rate and the changes of serum TGF-β and TNF-α necessary for understanding the underlying mechanisms of narrow-band UVB phototherapy. NB-UVB is effective against psoriasis without any obvious side effects and can significantly decrease serum TNF-α and promote TGF-β level of psoriasis patients. Additionally, measurement of TGF-β and TNF-αin serum could be considered as biomarkers of psoriasis activity during NB-UVB therapy.

American Journal of Applied Sciences
Volume 11 No. 12, 2014, 1992-1994

DOI: https://doi.org/10.3844/ajassp.2014.1992.1994

Submitted On: 29 March 2014 Published On: 6 January 2015

How to Cite: Khalaf, A. T. & Yuehua, Y. (2014). Serum TGF-β and TNF-α During Psoriasis Therapy with Narrowband Ultraviolet B. American Journal of Applied Sciences, 11(12), 1992-1994. https://doi.org/10.3844/ajassp.2014.1992.1994

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Keywords

  • Psoriasis
  • Narrow-Band Ultraviolet B (NB-UVB)
  • Serum Transforming Growth Factor-β (TGF-β)
  • Tumour Necrosis Factor-α(TNF-α)