Research Article Open Access

Emetine produce Entamoeba histolytica Death by Inducing a Programmed Cell Death

J.D. Villalba-Magdaleno1, R. Rojas1, C. Gómez1, M. Shibayama2, Julio C. Carrero2 and D.G.1
  • 1 Instituto Politécnico Nacional, Mexico
  • 2 Instituto de Investigaciones Biomédicas, Mexico

Abstract

Amoebiasis is a major public health problem in tropical and subtropical countries. Although a number of antiamoebic agents are used for its treatment and the molecular targets of these drugs have been identified, the biochemical and physiological mechanisms that produce trophozoite death are little known. The present study dates the in vitro induction of programmed cell death (PCD) in E. histolytica by emetine. Morphologically, the emetine incubation reduces cytoplasmic volume, produce nuclear condensation and DNA fragmentation, maintaining the plasma membrane integrity; biochemically, the morphological changes are in concordance with the overproduction of reactive oxygen species inside trophozoites. These results provide the first insight related the cellular mechanisms of emetine action.

American Journal of Infectious Diseases
Volume 3 No. 2, 2007, 110-114

DOI: https://doi.org/10.3844/ajidsp.2007.110.114

Submitted On: 17 April 2007 Published On: 30 June 2007

How to Cite: Villalba-Magdaleno, J., Rojas, R., Gómez, C., Shibayama, M., Carrero, J. C. & D.G., (2007). Emetine produce Entamoeba histolytica Death by Inducing a Programmed Cell Death. American Journal of Infectious Diseases, 3(2), 110-114. https://doi.org/10.3844/ajidsp.2007.110.114

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Keywords

  • Entamoeba histolytica
  • Programmed Cell Death
  • Emetine
  • Apoptosis