Letters to the Editor Open Access

Is Hydroxychloroquine a Safe and Effective Choice for Covid-19 Prophylaxis

Rodrigo Moisés de Almeida-Leite1, Tais Rondello Bonatti2, Carolina Rodrigues Ponzoni3, Ana Cristina da Cunha Korndorfer4 and Solange Bifani Tavares da Silva1
  • 1 Faculdade de Medicina de Jundiaí, Brazil
  • 2 Universidade Paulista, Brazil
  • 3 Unimed Itatiba, Brazil
  • 4 Faculdade de Medicina de Teresópolis, Brazil


The authors speculate about the possibility of Hydroxychloroquine as Covid-19 Phrophylaxis in the dose of 400 mg per week. The authors compared the experience of Malaria phrophylaxis in this dose, with acceptable safety profile. Also, we compared in vitro susceptibility of SARS-Cov-2 with that of Plasmodium falciparum. This agent show significant higher potency for the first. Also, the extended Half-life (40-50 days) make it an acceptable choice for prophylaxis. We also cite Brazilian experience with Chloroquinated Salt in the 1950s, its efficacy and feasibility. Lastly, we suggest that clinical trials should be conducted test this hypothesis.

American Journal of Infectious Diseases
Volume 16 No. 3, 2020, 118-119

DOI: https://doi.org/10.3844/ajidsp.2020.118.119

Submitted On: 16 April 2020 Published On: 29 July 2020

How to Cite: de Almeida-Leite, R. M., Bonatti, T. R., Ponzoni, C. R., Korndorfer, A. C. D. C. & da Silva, S. B. T. (2020). Is Hydroxychloroquine a Safe and Effective Choice for Covid-19 Prophylaxis. American Journal of Infectious Diseases, 16(3), 118-119. https://doi.org/10.3844/ajidsp.2020.118.119

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  • COVID-19
  • Pre-exposure Prophylaxis
  • Hydroxychloroquine